(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-pyrrolo[2,3-b]pyridin-2-yl]-methanone → HCID 73013561, compound

HRID 1437729Notes

Reaction equation

HRID 1437729 reaction equation
FC1(F)CCN(C(C2NC3=NC=C(OC4CCN(C(C)C)CC4)C=C3C=2)=O)CC1.[CH3:30][O:31][C:32]([C:34]1[N:51]([C:52]([O:54][C:55]([CH3:58])([CH3:57])[CH3:56])=[O:53])[C:37]2=[N:38][C:39]([Cl:50])=[C:40]([O:42]CC3C=CC=CC=3)[CH:41]=[C:36]2[CH:35]=1)=[O:33]>>[CH3:30][O:31][C:32]([C:34]1[N:51]([C:52]([O:54][C:55]([CH3:58])([CH3:57])[CH3:56])=[O:53])[C:37]2=[N:38][C:39]([Cl:50])=[C:40]([OH:42])[CH:41]=[C:36]2[CH:35]=1)=[O:33]

Participants

3

Reactant 2

HCID 16727356(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-pyrrolo[2,3-b]pyridin-2-yl]-methanoneHCID 73013558HCID 73013558, compound

Product 1

HCID 73013561HCID 73013561, compound

Procedure

The title compound was synthesized in analogy to example 9, intermediate b), through hydrogenation of 5-benzyloxy-6-chloro-pyrrolo[2,3-b]pyridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester to give the compound as a white solid (62%).

Sources & evidence

ORD record
ord-5309f6e5a4df479d9514ed8e73b49e3a
Source dataset
uspto-grants-2009_11
Patent number
US07622466B2

Reaction notes

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