HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 86625953, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-pyrrolo[2,3-b]pyridin-2-yl]-methanone | HCID 16727356 | — |
| Reactant | HCID 86625955 | HCID 86625955 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86625953 | HCID 86625953 | — |
Reaction Steps
The title compound was synthesized in analogy to example 13, intermediate b), from 6-chloro-5-(1-isopropyl-piperidin-4-yloxy)-pyrrolo[2,3-b]pyridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester and concentrated hydrochloric acid in dioxan after stirring at reflux temperature for 4 hours. The product was obtained as a light brown solid (>100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622466B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-388ac0d3dae342f7939c74bd33b76911 |
| Source note | uspto-grants-2009_11 |