Hydrochloric Acid → HCID 86625953, compound

HRID 1437730Notes

Reaction equation

HRID 1437730 reaction equation
FC1(F)CCN(C(C2NC3=NC=C(OC4CCN(C(C)C)CC4)C=C3C=2)=O)CC1.C[O:31][C:32]([C:34]1[N:53](C(OC(C)(C)C)=O)[C:37]2=[N:38][C:39]([Cl:52])=[C:40]([O:42][CH:43]3[CH2:48][CH2:47][N:46]([CH:49]([CH3:51])[CH3:50])[CH2:45][CH2:44]3)[CH:41]=[C:36]2[CH:35]=1)=[O:33].Cl>O1CCOCC1>[ClH:52].[Cl:52][C:39]1[N:38]=[C:37]2[NH:53][C:34]([C:32]([OH:33])=[O:31])=[CH:35][C:36]2=[CH:41][C:40]=1[O:42][CH:43]1[CH2:44][CH2:45][N:46]([CH:49]([CH3:51])[CH3:50])[CH2:47][CH2:48]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 16727356(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-pyrrolo[2,3-b]pyridin-2-yl]-methanoneHCID 86625955HCID 86625955, compound

Product 1

HCID 86625953HCID 86625953, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title compound was synthesized in analogy to example 13, intermediate b), from 6-chloro-5-(1-isopropyl-piperidin-4-yloxy)-pyrrolo[2,3-b]pyridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester and concentrated hydrochloric acid in dioxan after stirring at reflux temperature for 4 hours. The product was obtained as a light brown solid (>100%).

Workup

  1. temperatureat reflux temperature for 4 hours

Sources & evidence

ORD record
ord-388ac0d3dae342f7939c74bd33b76911
Source dataset
uspto-grants-2009_11
Patent number
US07622466B2

Reaction notes

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