Water → HCID 86615228, compound

HRID 1437774Notes

Reaction equation

HRID 1437774 reaction equation
C[O:2][C:3](=[O:16])[C@@H:4]([OH:15])[CH2:5][CH2:6][NH:7][C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9].O.[OH-].[Li+:19].O>CO>[C:11]([O:10][C:8]([NH:7][CH2:6][CH2:5][C@H:4]([OH:15])[C:3]([O-:16])=[O:2])=[O:9])([CH3:14])([CH3:12])[CH3:13].[Li+:19]

Participants

5

Reactant 3

HCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 54753949HCID 54753949, compound

Product 1

HCID 86615228HCID 86615228, compoundYield 85.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of (S)-4-tert-butoxycarbonylamino-2-hydroxybutyric acid methyl ester (1.52 g, 6.52 mmol) in methanol (20.0 mL) was treated with lithium hydroxide monohydrate (273.8 mg, 6.52 mmol) and water (2.0 mL) for 30 min, concentrated, and dried under vacuum to give a white solid (1.26 g)

Workup

  1. concentrationconcentrated
  2. customdried under vacuum

Sources & evidence

ORD record
ord-90b71f8a96e94b38a70fd1a3c659e3c1
Source dataset
uspto-grants-2009_11
Patent number
US07622508B2

Reaction notes

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