Glycolide → HCID 6453016, compound

Participants

Reaction Steps

An operation was conducted in the same manner as in Example 14 except that 21,375 g (glycolic acid: 60 ppm, glycolic acid dimer: 570 ppm, water: 30 ppm; overall proton concentration of impurities: 0.078 mol %) of glycolide and 1,125 g (lactic acid: 0 ppm, lactic acid dimer: 270 ppm, water: 8 ppm; overall proton concentration of impurities: 0.030 mol %) of L-lactide were used, and 1.12 g [in view of the amount (0.31 g) of water (moisture) contained in an atmosphere within the container] of water were added to control the overall proton concentration (set proton concentration) to 0.117 mol %. After completion of the polymerization, the yield of bulk matter of a poly(glycolic acid/L-lactic acid) copolymer formed was almost 100%. The results are shown in Table 6.

Provenance & Evidence