Glycolide → HCID 6453016, compound

HRID 1437786Notes

Reaction equation

HRID 1437786 reaction equation
[CH2:1]1[O:8]C(=O)C[O:4][C:2]1=[O:3].[CH3:9][C@@H:10]1[O:17]C(=O)[C@H](C)[O:13][C:11]1=[O:12]>O>[C:2]([OH:4])(=[O:3])[CH2:1][OH:8].[C:11]([OH:13])(=[O:12])[C@H:10]([CH3:9])[OH:17]

Participants

4

Reactant 2

HCID 65432GlycolideHCID 107983Lactide, L-

Product 1

HCID 6453016HCID 6453016, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

An operation was conducted in the same manner as in Example 14 except that 21,375 g (glycolic acid: 60 ppm, glycolic acid dimer: 570 ppm, water: 30 ppm; overall proton concentration of impurities: 0.078 mol %) of glycolide and 1,125 g (lactic acid: 0 ppm, lactic acid dimer: 270 ppm, water: 8 ppm; overall proton concentration of impurities: 0.030 mol %) of L-lactide were used, and 1.12 g [in view of the amount (0.31 g) of water (moisture) contained in an atmosphere within the container] of water were added to control the overall proton concentration (set proton concentration) to 0.117 mol %. After completion of the polymerization, the yield of bulk matter of a poly(glycolic acid/L-lactic acid) copolymer formed was almost 100%. The results are shown in Table 6.

Workup

  1. additionwere added
  2. concentrationthe overall proton concentration (set proton concentration) to 0.117 mol %
  3. customAfter completion of the polymerization

Sources & evidence

ORD record
ord-bb66d73673ed4e5d84c05a18564547a4
Source dataset
uspto-grants-2009_11
Patent number
US07622546B2

Reaction notes

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