Methanesulfonic Acid → HCID 178505262, compound

HRID 1437855Notes

Reaction equation

HRID 1437855 reaction equation
[CH3:1][S:2]([C:5]1[C:6]([S:18]([F:23])([F:22])([F:21])([F:20])[F:19])=[CH:7][C:8]([CH3:17])=[C:9]([CH:16]=1)[C:10]([NH:12][C:13]([NH2:15])=[NH:14])=[O:11])(=[O:4])=[O:3].[CH3:24][S:25]([OH:28])(=[O:27])=[O:26]>O>[CH3:24][S:25]([OH:28])(=[O:27])=[O:26].[CH3:1][S:2]([C:5]1[C:6]([S:18]([F:22])([F:23])([F:19])([F:20])[F:21])=[CH:7][C:8]([CH3:17])=[C:9]([CH:16]=1)[C:10]([NH:12][C:13]([NH2:15])=[NH:14])=[O:11])(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 178429696HCID 178429696, compound

Product 1

HCID 178505262HCID 178505262, compoundYield 102.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

9.3 g of the title compound of example 1 were suspended in 100 ml of water and a solution of 2.3 g of methanesulfonic acid in 10 ml of water was added. The mixture was subsequently stirred at RT for 30 minutes and then the water was removed under reduced pressure to obtain 11.7 g of the methanesulfonic acid salt, which was subsequently recrystallized from 110 ml of water to obtain 10.0 g of N-(5-methanesulfonyl-2-methyl-4-pentafluorosulfanylbenzoyl)guanidine methanesulfonic acid salt as white crystals, m.p. 230° C.

Workup

  1. customthe water was removed under reduced pressure

Sources & evidence

ORD record
ord-7d6dbb8b718449a3ad96e1a0fad1dfd7
Source dataset
uspto-grants-2009_11
Patent number
US07622611B2

Reaction notes

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