Benzyl Bromide → HCID 69018021, compound

HRID 1437919Notes

Reaction equation

HRID 1437919 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:16](=[O:17])[C:15]2[C@@H:14]3[C:18]([CH3:20])([CH3:19])[C@@:11]([CH3:21])([CH2:12][CH2:13]3)[C:10]=2[NH:9]1.[CH2:22](Br)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.ClC1C=CC=CC=1N1C(=O)C2[C@@H]3C(C)(C)[C@@](C)(CC3)C=2N1CC>>[CH2:22]([N:9]1[C:10]2[C:11]3([CH3:21])[C:18]([CH3:20])([CH3:19])[CH:14]([CH2:13][CH2:12]3)[C:15]=2[C:16](=[O:17])[N:8]1[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:1])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

4

Reactant 3

HCID 7498Benzyl BromideHCID 57941362HCID 57941362, compound2×HCID 57941485HCID 57941485, compound

Product 1

HCID 69018021HCID 69018021, compound

Procedure

Benzyl-2-(2-chloro-phenyl)-7,8,8-trimethyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one was prepared from (4S,7R)-2-(2-chloro-phenyl)-7,8,8-trimethyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one (Intermediate 10) and benzyl bromide using the procedure described above for the preparation of (4S,7R)-2-(2-chloro-phenyl)-1-ethyl-7,8,8-trimethyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one (Example 9). APCI-MS (M+H) 393.

Sources & evidence

ORD record
ord-4e34414d3ad340b28cba3acd67858ba6
Source dataset
uspto-grants-2009_11
Patent number
US07622492B2

Reaction notes

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