Potassium Carbonate → HCID 57941497, compound

HRID 1437958Notes

Reaction equation

HRID 1437958 reaction equation
I[C:2]1[CH:3]=[C:4]([N:8]2[C:16](=[O:17])[C:15]3[CH:14]4[C:18]([CH3:20])([CH3:19])[C:11]([CH3:21])([CH2:12][CH2:13]4)[C:10]=3[N:9]2[CH3:22])[CH:5]=[CH:6][CH:7]=1.[CH3:23][C:24]1[CH:25]=[C:26](B(O)O)[CH:27]=[CH:28][CH:29]=1.C(=O)([O-])[O-].[K+].[K+]>C(COC)OC.ClCCl.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[CH3:22][N:9]1[C:10]2[C@@:11]3([CH3:21])[C:18]([CH3:19])([CH3:20])[C@H:14]([CH2:13][CH2:12]3)[C:15]=2[C:16](=[O:17])[N:8]1[C:4]1[CH:3]=[C:2]([C:28]2[CH:27]=[CH:26][CH:25]=[C:24]([CH3:23])[CH:29]=2)[CH:7]=[CH:6][CH:5]=1

Participants

7

Reactant 3

HCID 11430Potassium CarbonateHCID 27339503-Tolylboronic acidHCID 69018350HCID 69018350, compound

Product 1

HCID 57941497HCID 57941497, compoundYield 20.1%

Reagents, catalysts & solvents 3

HCID 178418228Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)CatalystHCID 6344DichloromethaneSolventHCID 80711,2-DimethoxyethaneSolvent

Procedure

A mixture of 2-(3-iodo-phenyl)-1,7,8,8-tetramethyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one (Example 23; 80 mg, 0.2 mmol), 3-methyl-phenyl-boronic acid (41 mg, 0.29 mmol), potassium carbonate (66 mg, 0.47 mmol) and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (10 mg, 0.014 mmol) in dimethoxyethane (4 mL) was sealed under argon and heated at 80 degrees overnight and then at 90 degrees over the weekend. The reaction mixture was diluted with dichloromethane, filtered through a cotton plug and frit, evaporated, and purified using an Analogix Intelliflash 280 system (Analogix, Inc., Burlington, Wis.) with an RS-12 column, eluting with 0-35% ethyl acetate/hexanes to give (4S,7R)-1,7,8,8-tetramethyl-2-(3′-methyl-biphenyl-3-yl)-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one (15 mg, 20%) as a brown solid. ES(+)-MS (M+H) 373.

Workup

  1. customwas sealed under argon
  2. temperatureheated at 80 degrees overnight
  3. customat 90 degrees
  4. filtrationfiltered through a cotton plug and frit
  5. customevaporated
  6. custompurified
  7. washeluting with 0-35% ethyl acetate/hexanes

Sources & evidence

ORD record
ord-3527c1d606124f6f835020bcef0a4c78
Source dataset
uspto-grants-2009_11
Patent number
US07622492B2

Reaction notes

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