反应详情

650 mg (0.0015 mole) of N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-(1-acetoxy-2-fluoroethyl)-2-thiophenesulfonamide synthesized in Example 4 was dissolved in 5 ml of aqueous sodium hydroxide solution and then stirred at normal temperature for one hour. The reaction mixture was adjusted to pH4 by adding 5% aqueous HCl solution and then extracted with methylene chloride. The extract was concentrated to obtain 540 mg (Yield: 92%) of the pure title compound.

1. extractionextracted with methylene chloride
2. concentrationThe extract was concentrated