Hydrochloric Acid → HCID 19690770, compound

HRID 1438Notes

Reaction equation

HRID 1438 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([NH:11][C:12]([NH:14][S:15]([C:18]2[S:19][CH:20]=[CH:21][C:22]=2[CH:23]([O:26]C(=O)C)[CH2:24][F:25])(=[O:17])=[O:16])=[O:13])[N:4]=1.Cl>[OH-].[Na+]>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([NH:11][C:12]([NH:14][S:15]([C:18]2[S:19][CH:20]=[CH:21][C:22]=2[CH:23]([OH:26])[CH2:24][F:25])(=[O:16])=[O:17])=[O:13])[N:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19690773N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-3-(1-acetoxy-2-fluoroethyl)-2-thiophenesulfonamide

Product 1

HCID 19690770HCID 19690770, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

650 mg (0.0015 mole) of N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-(1-acetoxy-2-fluoroethyl)-2-thiophenesulfonamide synthesized in Example 4 was dissolved in 5 ml of aqueous sodium hydroxide solution and then stirred at normal temperature for one hour. The reaction mixture was adjusted to pH4 by adding 5% aqueous HCl solution and then extracted with methylene chloride. The extract was concentrated to obtain 540 mg (Yield: 92%) of the pure title compound.

Workup

  1. extractionextracted with methylene chloride
  2. concentrationThe extract was concentrated

Sources & evidence

ORD record
ord-9db8bda42ddd42569da026335543c4dd
Source dataset
uspto-grants-1998_03
Patent number
US05726127

Reaction notes

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