Hydrochloric Acid → HCID 68436566, compound

HRID 1438150Notes

Reaction equation

[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([O:9][CH3:10])=[CH:4][C:3]=1[CH:11]([OH:14])[C:12]#[N:13].CO.[ClH:17].[O:18]1CCOC[CH2:19]1>C(OCC)C>[ClH:17].[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([O:9][CH3:10])=[CH:4][C:3]=1[CH:11]([OH:14])[C:12](=[NH:13])[O:18][CH3:19]

Participants

Conditions

Temperature: 4 °C

Procedure

To 98B (427 mg, 2.1 mmol) in anhydrous diethyl ether (10 mL) at 0° C. was added MeOH (0.87 mL, 10 eq.) and 4.0 N HCl in dioxane (4.2 mL, 16.8 mmol). The mixture was stirred at 4° C. for 24 h. Solvent was removed to give methyl 2-(2,4-difluoro-5-methoxyphenyl)-2-hydroxyacetimidate HCl salt. To this salt in CH2Cl2 (8.0 mL) was added H2O (8.0 mL). The mixture was stirred at rt for 30 min, then extracted with CH2Cl2 (2×50 mL). The combined organic extracts were dried and concentrated to give product 98C (493 mg, 99% yield) as a white solid. 1H NMR (400 MHz, CDCl3) δ ppm 3.41 (d, J=4.83 Hz, 1H) 3.72 (s, 3H) 3.80 (s, 3H) 5.32 (d, J=4.83 Hz, 1H) 6.78-6.84 (m, 1H) 6.90 (dd, J=9.01, 6.81 Hz, 1H).

Workup

customSolvent was removed

Sources & evidence

ORD record: ord-76110516a9794e1593957c2a0c102212
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07622585B2

Reaction notes

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