3-Ethoxy-5-ethyl-2-fluorobenzaldehyde → 5-Ethyl-2-fluoro-3-methoxybenzaldehyde

HRID 1438161Notes

Reaction equation

HRID 1438161 reaction equation
[Si](OC1C(F)=C(C=C(CC)C=1)C=O)(C(C)(C)C)(C)C.[CH2:20]([O:22][C:23]1[C:24]([F:33])=[C:25]([CH:28]=[C:29]([CH2:31][CH3:32])[CH:30]=1)[CH:26]=[O:27])C>>[CH2:31]([C:29]1[CH:30]=[C:23]([O:22][CH3:20])[C:24]([F:33])=[C:25]([CH:28]=1)[CH:26]=[O:27])[CH3:32]

Participants

3

Reactant 2

HCID 579428023-Ethoxy-5-ethyl-2-fluorobenzaldehydeHCID 598380723-{[tert-Butyl(dimethyl)silyl]oxy}-5-ethyl-2-fluorobenzaldehyde

Product 1

HCID 598380485-Ethyl-2-fluoro-3-methoxybenzaldehyde

Procedure

119A was prepared from 118C using a procedure similar to that used in the preparation of 118D. 1H NMR (400 MHz, CDCl3) δ ppm 1.23 (t, J=7.47 Hz, 3H) 2.64 (q, J=7.62 Hz, 2H) 3.92 (s, 3H) 7.02 (dd, J=8.13, 1.98 Hz, 1H) 7.23 (dd, J=5.27, 2.20 Hz, 1H) 10.35 (s, 1H).

Sources & evidence

ORD record
ord-13ccbfa0e1c4440785fb163ac0a4f639
Source dataset
uspto-grants-2009_11
Patent number
US07622585B2

Reaction notes

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