Hydrochloric Acid → 1'-[(5-fluoropyridin-3-yl)methyl]-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-2'(1'H)-one

HRID 143827Notes

Reaction equation

HRID 143827 reaction equation
[C:23](=[O:24])([O-:25])[O-:26].[CH2:47]([N+:48]([CH2:49][CH2:50][CH2:51][CH3:52])([CH2:53][CH2:54][CH2:55][CH3:56])[CH2:57][CH2:58][CH2:59][CH3:60])[CH2:61][CH2:62][CH3:63].[CH3:41][C:42](=[O:43])[CH2:44][CH3:45].[Cl:30][CH2:31][c:32]1[cH:33][n:34][cH:35][c:36]([F:38])[cH:37]1.[ClH:29].[Cs+:27].[Cs+:28].[I-:40].[I-:46].[K+:39].[NH:1]1[C:2](=[O:22])[C:3]2([CH2:4][O:5][c:6]3[cH:7][c:8]4[c:9]([cH:14][c:15]32)[O:10][CH2:11][CH2:12][O:13]4)[c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21>>[N:1]1([CH2:31][c:32]2[cH:33][n:34][cH:35][c:36]([F:38])[cH:37]2)[C:2](=[O:22])[C:3]2([CH2:4][O:5][c:6]3[cH:7][c:8]4[c:9]([cH:14][c:15]32)[O:10][CH2:11][CH2:12][O:13]4)[c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21

Participants

10

Reactant 9

HCID 313Hydrochloric AcidHCID 813Potassium CationHCID 6569Methyl Ethyl KetoneHCID 16028TetrabutylammoniumHCID 19660Carbonate IonHCID 30165Iodide Ion2×HCID 104967Cesium cation2×HCID 216984253-(Chloromethyl)-5-fluoropyridineHCID 58224164Spiro[furo[2,3-g]-1,4-benzodioxin-8(7H),3'-[3H]indol]-2'(1'H)-one, 2,3-dihydro

Product 1

HCID 593524761'-[(5-fluoropyridin-3-yl)methyl]-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-dd696662d6d24aa19ee0db3b619ff3e0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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