4-[4-(Pyridin-2-ylsulfanylcarbonyl)-butyl]-piperidine-1-carboxylic acid tert-butyl ester → 4-(5-Cyclopentyl-5-oxo-pentyl)-piperidine-1-carboxylic acid tert-butyl ester
Reaktionsgleichung
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][CH2:17][C:18](SC2C=CC=CN=2)=[O:19])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].N1C=CC=CC=1SC(=O)CC[CH:37]1[CH2:42][CH2:41][CH2:40][CH2:39]C1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][CH2:15][CH2:16][CH2:17][C:18]([CH:39]2[CH2:40][CH2:41][CH2:42][CH2:37]2)=[O:19])[CH2:12][CH2:13]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]Komponenten
3
Versuchsvorschrift
The title compound was prepared analogously to step 7 of example B(29) where 4-[4-(pyridin-2-ylsulfanylcarbonyl)-butyl]-piperidine-1-carboxylic acid tert-butyl ester from step 5 above, was substituted in place 3-cyclohexyl-thiopropionic acid S-pyridin-2-yl ester. 1H NMR (400 MHz, CDCl3): δ 1-1.42 (m, 8H), 1.45 (s, 9H), 1.50-1.84 (m, 14H), 2.42-2.46 (m, 2H), 2.62-2.7 (m, 2H), 2.82-2.87 (m, 1H). ESIMS (MH+): 337.
Quellen und Nachweise
- ORD-Eintrag
- ord-f06f5552367047339c56bf0f9b5e14f5
- Quelldatensatz
- uspto-grants-2009_11
- Patentnummer
- US07622605B2
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