Water → N-methoxy-N-methylcyclopentanecarboxamide

Cyclopentane carbonyl chloride (65 g, 0.49 mol) was added dropwise into a mixture of Et3N (180 mL, 1.3 mol) and N,O-dimethyl hydroxylamine hydrochloride (50 g, 0.52 mol) in anhydrous CH2Cl2 at 0° C. After the addition, the reaction mixture was allowed to stir at ambient temperature overnight. To the reaction mixture was added about 100 g of crushed ice followed 100 g of water. The mixture was separated, and the aqueous layer was extracted with CH2Cl2 (100 mL×2). The combined organic layers were washed with 1N HCl, water, brine and dried over Na2SO4. The solvent was removed under reduced pressure to afford 61 g of desired product as oil in 78.8% of yield.

1. additionAfter the addition
2. customThe mixture was separated
3. extractionthe aqueous layer was extracted with CH2Cl2 (100 mL×2)
4. washThe combined organic layers were washed with 1N HCl, water, brine
5. dry with materialdried over Na2SO4
6. customThe solvent was removed under reduced pressure

ORD record

ord-2cee3957434347928daf7e5f93389384

Source dataset

uspto-grants-2009_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07622605B2