HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 6-tert-Butyl-2-piperidin-1-ylnicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 6-Tert-butyl-2-chloropyridine-3-carbonitrile | HCID 53278876 | — |
| Product | 6-tert-Butyl-2-piperidin-1-ylnicotinonitrile | HCID 58873526 | 98% |
Reaction Steps
A mixture of 6-tert-butyl-2-chloronicotinonitrile (Tetrahedron 1965, 21, 2453-2467, 1.5 g, 7.7 mmol) and piperidine (15 ml, 176 mmol) was stirred for 20 hours at room temperature. Then the reaction mixture was evaporated to remove piperidine in vacuo to give the title compound (1.8 g, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07622589B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-80d446bf3b074083b1f562d054f90ae1 |
| Source note | uspto-grants-2009_11 |