Piperidine → 6-tert-Butyl-2-piperidin-1-ylnicotinonitrile

HRID 1438396Notes

Reaction equation

HRID 1438396 reaction equation
[C:1]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7](Cl)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>>[C:1]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 8082PiperidineHCID 532788766-Tert-butyl-2-chloropyridine-3-carbonitrile

Product 1

HCID 588735266-tert-Butyl-2-piperidin-1-ylnicotinonitrileYield 98%

Procedure

A mixture of 6-tert-butyl-2-chloronicotinonitrile (Tetrahedron 1965, 21, 2453-2467, 1.5 g, 7.7 mmol) and piperidine (15 ml, 176 mmol) was stirred for 20 hours at room temperature. Then the reaction mixture was evaporated to remove piperidine in vacuo to give the title compound (1.8 g, 98%).

Workup

  1. customThen the reaction mixture was evaporated
  2. customto remove piperidine in vacuo

Sources & evidence

ORD record
ord-80d446bf3b074083b1f562d054f90ae1
Source dataset
uspto-grants-2009_11
Patent number
US07622589B2

Reaction notes

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