Diethyl Ether → HCID 67046609, compound

HRID 1438409Notes

Reaction equation

HRID 1438409 reaction equation
[CH2:1](OCC)C.[N:6]1([C:12]2[C:17]([CH:18]=[O:19])=[CH:16][CH:15]=[C:14]([C:20]([F:23])([F:22])[F:21])[N:13]=2)[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1.C[Mg]Cl>C1COCC1>[N:6]1([C:12]2[C:17]([CH:18]([OH:19])[CH3:1])=[CH:16][CH:15]=[C:14]([C:20]([F:23])([F:21])[F:22])[N:13]=2)[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 11299934HCID 11299934, compoundHCID 178418332HCID 178418332, compound

Product 1

HCID 67046609HCID 67046609, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a diethylether (7.0 ml) solution of 2-morpholin-4-yl-6-(trifluoromethyl)pyridine-3-carbaldehyde (Jornal of Medicinal Chemistry, 2005, 48, p 71-90, 0.88 g, 3.4 mmol) was added THF solution of methylmagnesiumchloride (3.0M, 1.36 ml) at 0° C. and the mixture was stirred for 0.5 h. The same procedure as described in Example 9C was performed to give the title compound as a colorless oil (quant. 0.9 g).

Sources & evidence

ORD record
ord-b7f9fa4d78324ce2afc3dc0b24474575
Source dataset
uspto-grants-2009_11
Patent number
US07622589B2

Reaction notes

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