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HRID1438524

反应详情

EQUATION

反应方程式

HRID 1438524 的结构方程式

REACTANTS

反应物

3
结构：CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1
HCID111923

Propylphosphonic anhydride

C9H21O6P3

结构：Fc1cccc2c1OCCN2
HCID16244451

8-Fluoro-3,4-dihydro-2H-1,4-benzoxazine

C8H8FNO

结构：O=C(O)c1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1
HCID57942077

未命名化合物

PRODUCTS

生成物

1
结构：O=C(c1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1)N1CCOc2c(F)cccc21
HCID57942421

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCN(CC)CC
溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine, 5-chloro-3-(4-chloro-3-(trifluoromethyl)phenylsulfonamido)picolinic acid, T3P, and Et3N were reacted according to the procedure D to provide the title compound. HPLC purification provided 4-chloro-N-[5-chloro-2-(8-fluoro-2,3-dihydro-benzo[1,4]oxazine-4-carbonyl)-pyridin-3-yl]-3-trifluoromethyl-benzenesulfonamide. Reverse phase HPLC gradient acetonitrile 0.1% TFA 20-95% in 4 min: 2.986 min. MS m/z 550.1 (M+H).