反应详情

A mixture of 4-Chloro-N-[5-chloro-2-(2-oxazol-2-yl-benzoyl)-pyridin-3-yl]-N-methoxymethyl-3-trifluoromethyl-benzenesulfonamide(15 mg) in 2 mL of 4M HCl in dioxane and 1 mL of water was refluxed for 2 hours. After cooling to rt the mixture was concentrated, diluted with water and then sodium bicarbonate was added until pH was 6. The mixture was extracted with ethyl acetate, dried and concentrated. The residue was purified via flash column (35% ethyl acetate in hexane) to afford 8.0 mg of title compound as an off white solid. MS: (M+H)/z=542.3.

1. concentrationwas concentrated
2. additiondiluted with water
3. additionsodium bicarbonate was added until pH was 6
4. extractionThe mixture was extracted with ethyl acetate
5. customdried
6. concentrationconcentrated
7. customThe residue was purified via flash column (35% ethyl acetate in hexane)