反应详情

3-{[5-chloro-3-(4-chloro-3-trifluoromethyl-benzenesulfonylamino)-pyridine -2-carbonyl]-ethyl-amino}-pyrazole-1-carboxylic acid tert-butyl ester from step 2 was dissolved in a mixture of DCM and TFA (1:1) (5 mL). It was stirred at RT for 1 hour, concentrated, purified with HPLC to give 5-chloro-3-(4-chloro-3-trifluoromethyl-benzenesulfonylamino)-pyridine-2-carboxylic acid ethyl-(1H-pyrazol-3-yl)-amide: 1H NMR (400 MHz, CDCl3) δ 8.11 (d, 1 H), 8.0 (d, 1 H), 7.94 (m, 1 H), 7.88 (br, 1 H), 7.6 (d, 1 H), 7.37 (br, 1 H), 5.8 (s, 1 H), 3.8 (m, 2H), 1.1 (m, 3H); MS m/z: 508 (M+H)+.

1. concentrationconcentrated
2. custompurified with HPLC