反应详情

温度

90 °C

4-tert-Butyl-N-[5-chloro-2-(6-cyano-pyridine-3-carbonyl)-pyridin-3-yl]-N-methoxymethyl-benzenesulfonamide (15 mg, 0.030 mmol) was dissolved in 4N HCl (500 μL) and dioxane (1 mL). The reaction was then stirred at 90° C. for 12 hours. The solvent was removed under reduced pressure and the crude solid was purified by preparatory TLC (1:4 EtOAc/hexanes) to give 5 mg (0.01 mmol, 40% yield) of the desired product as a white solid. MS calc'd for C22H20ClN4O3S (MH+): expected 455.1, found 455.0.

1. customThe solvent was removed under reduced pressure
2. customthe crude solid was purified by preparatory TLC (1:4 EtOAc/hexanes)