Water → HCID 68118631, compound

Participants

Reaction Steps

For example, 2,7-dichloro-5-(o-chlorophenyl)-3-methoxy-3H-1,4-benzodiazepine is treated in a mixture of tetrahydrofuran and ethanol, at room temperature with sodium ethoxide. After addition of water, the reaction mixture is partitioned with diethyl ether, and the organic phase is then dried, concentrated and the crystalline product so formed, recovered to give 7-chloro-5-(o-chlorophenyl)-2-ethoxy-2-methoxy-3H-1,4-benzodiazepine.

Provenance & Evidence