Water → HCID 68118631, compound

HRID 1438691Notes

Reaction equation

HRID 1438691 reaction equation
Cl[C:2]1[CH:8](OC)[N:7]=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[Cl:17])[C:5]2[CH:18]=[C:19]([Cl:22])[CH:20]=[CH:21][C:4]=2[N:3]=1.[O-:23][CH2:24][CH3:25].[Na+].O.[O:28]1CCC[CH2:29]1>C(O)C>[Cl:22][C:19]1[CH:20]=[CH:21][C:4]2[NH:3][C:2]([O:23][CH2:24][CH3:25])([O:28][CH3:29])[CH2:8][N:7]=[C:6]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[Cl:17])[C:5]=2[CH:18]=1

Participants

6

Reactant 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 2723922Sodium ethoxideHCID 214002202,7-Dichloro-5-(2-chlorophenyl)-3-methoxy-3H-1,4-benzodiazepine

Product 1

HCID 68118631HCID 68118631, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

For example, 2,7-dichloro-5-(o-chlorophenyl)-3-methoxy-3H-1,4-benzodiazepine is treated in a mixture of tetrahydrofuran and ethanol, at room temperature with sodium ethoxide. After addition of water, the reaction mixture is partitioned with diethyl ether, and the organic phase is then dried, concentrated and the crystalline product so formed, recovered to give 7-chloro-5-(o-chlorophenyl)-2-ethoxy-2-methoxy-3H-1,4-benzodiazepine.

Workup

  1. customthe reaction mixture is partitioned with diethyl ether
  2. customthe organic phase is then dried
  3. concentrationconcentrated
  4. customthe crystalline product so formed
  5. customrecovered

Sources & evidence

ORD record
ord-c93392f83b5a40c48aa317cda4d49ea6
Source dataset
uspto-grants-1977_11
Patent number
US04056525

Reaction notes

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