Ethyl propiolate → 1-(4-Chloro-benzyl)-pyrazol-5-one

HRID 1438716Notes

Reaction equation

HRID 1438716 reaction equation
C(O[C:4](=[O:7])[C:5]#[CH:6])C.[Cl:8][C:9]1[CH:17]=[CH:16][C:12]([CH2:13][NH:14][NH2:15])=[CH:11][CH:10]=1>C(O)CCC>[Cl:8][C:9]1[CH:17]=[CH:16][C:12]([CH2:13][N:14]2[C:4](=[O:7])[CH:5]=[CH:6][NH:15]2)=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 12182Ethyl propiolateHCID 3015209(4-Chlorobenzyl)hydrazine

Product 1

HCID 233342501-(4-Chloro-benzyl)-pyrazol-5-one

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

9.8 g (0.1 mol) of propiolic acid ethyl ester and 15.6 g (0.1 mol) of p-chlorobenzylhydrazine in 100 ml of n-butanol were heated for 8 hours under reflux.

Workup

  1. temperatureunder reflux

Sources & evidence

ORD record
ord-d2efeb776f954a50bc01176eddbbda63
Source dataset
uspto-grants-1977_11
Patent number
US04056533

Reaction notes

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