Acetic Acid → HCID 20310613, compound

HRID 1438719Notes

Reaction equation

HRID 1438719 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[N:11]([CH:12]=1)[CH:10]=[CH:9][C:8]1[CH:13]=[CH:14][CH:15]=[CH:16][C:7]=1[C:6]2=[O:17])#[N:2].Cl.C(O)(=[O:21])C>>[C:1]([C:3]1[CH:4]=[C:5]2[N:11]([CH:12]=1)[CH:10]=[CH:9][C:8]1[CH:13]=[CH:14][CH:15]=[CH:16][C:7]=1[C:6]2=[O:17])(=[O:21])[NH2:2]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 13154188HCID 13154188, compound

Product 1

HCID 20310613HCID 20310613, compound

Procedure

2-Cyano-11H-pyrrolo[2,1-b][3]benzazepin-11-one (30 g., 0.135 mole) in 100 ml. of concentrated hydrochloric acid and 100 ml. of acetic acid is refluxed for 2 hours. It is then poured onto 500 ml. of water and continuously extracted with methylene chloride. The solution is left to cool to room temperature and filtered to afford 2-carbamoyl-11H-pyrrolo[2,1-b][3]benzazepin-11-one.

Workup

  1. additionIt is then poured onto 500 ml
  2. extractionof water and continuously extracted with methylene chloride
  3. waitThe solution is left
  4. filtrationfiltered

Sources & evidence

ORD record
ord-9d7a88e8fa5944d2ab16d6d47bb97b33
Source dataset
uspto-grants-1977_11
Patent number
US04056536

Reaction notes

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