Hydroxyamine hydrochloride → HCID 73997431, compound

HRID 1438741Notes

Reaction equation

HRID 1438741 reaction equation
[CH3:1][C:2]1([CH:15]=O)[C:7]2[NH:8][C:9]3[C:14]([C:6]=2[CH2:5][CH2:4][O:3]1)=[CH:13][CH:12]=[CH:11][CH:10]=3.Cl.[NH2:18][OH:19].C([O-])(=O)C.[Na+]>CO>[CH3:1][C:2]1([CH:15]=[N:18][OH:19])[C:7]2[NH:8][C:9]3[C:14]([C:6]=2[CH2:5][CH2:4][O:3]1)=[CH:13][CH:12]=[CH:11][CH:10]=3

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 22766917HCID 22766917, compound

Product 1

HCID 73997431HCID 73997431, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 1-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-carboxaldehyde (547 mg), described in Example 777, aqueous hydroxylamine hydrochloride (2.5 ml of 5N) and aqueous sodium acetate (2.5 ml of 5N) and methanol (5 ml) is heated at 50° - 60° C. for 5 min. and then kept at 4° C. for 16 hr. The precipitate is collected and recrystallized from ethanol water to afford 1-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-carboxaldehyde oxime, m.p. 176° - 178° C.

Workup

  1. temperatureis heated at 50° - 60° C. for 5 min.
  2. customThe precipitate is collected
  3. customrecrystallized from ethanol water

Sources & evidence

ORD record
ord-fb02f3c35f2c4481a68f6d3be196f0c0
Source dataset
uspto-grants-1977_11
Patent number
US04056537

Reaction notes

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