Methyl iodide → HCID 23050531, compound

HRID 1438837Notes

Reaction equation

HRID 1438837 reaction equation
[CH3:1]I.[NH2:3][N:4]1[C:9](=[O:10])[C:8]([CH:11]([CH2:13][CH3:14])[CH3:12])=[N:7][NH:6][C:5]1=[S:15].[OH-].[Na+]>O>[NH2:3][N:4]1[C:9](=[O:10])[C:8]([CH:11]([CH2:13][CH3:14])[CH3:12])=[N:7][N:6]=[C:5]1[S:15][CH3:1]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 13424984HCID 13424984, compound

Product 1

HCID 23050531HCID 23050531, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

66 ml of methyl iodide were added to a solution of 200 g of 4-amino-6-sec.-butyl-3-thioxo-1,2,4-triazin-5(2H,4H)-one in a solution of 40 g of sodium hydroxide in 1 liter of water, at 20° C, whilst stirring. When the slightly exothermic reaction had subsided, stirring was continued until the pH value reached 7 - 8 and the reaction product which had crystallized out was filtered off and washed with cold water. After drying, 205 g (96%) of 4-amino-6-sec.-butyl-3-methylthio-1,2,4-triazin-5(4H)-one were obtained, melting point 60° C (from carbon tetrachloride/petroleum ether).

Workup

  1. customWhen the slightly exothermic reaction
  2. stirringstirring
  3. customthe reaction product which had crystallized out
  4. filtrationwas filtered off
  5. washwashed with cold water
  6. customAfter drying

Sources & evidence

ORD record
ord-9f1ce2608e1f465eb82edd7c11c44417
Source dataset
uspto-grants-1977_11
Patent number
US04057417

Reaction notes

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