反应详情

A mixture of 372 g (4 mols) of aniline and 230 g (1 mol) of ω-chloroparaphenyl-acetophenone was refluxed for 105 minutes. After cooling to about 50°-80° C, the mixture was poured into iced-water containing 50 ml of concentrated hydrochloric acid to give a precipitate which was filtered out, washed with water, dried and then recrystallized from N,N-dimethylformamide. The pure substance was then filtered out and washed with ethanol to give 67.2 g of 2-(4'-phenyl-phenyl)-indole.

1. temperaturewas refluxed for 105 minutes
2. temperatureAfter cooling to about 50°-80° C
3. customto give a precipitate which
4. filtrationwas filtered out
5. washwashed with water
6. customdried
7. customrecrystallized from N,N-dimethylformamide
8. filtrationThe pure substance was then filtered out
9. washwashed with ethanol