Hydrochloric Acid → HCID 22797793, compound

Participants

Reaction Steps

In 30 ml of tetrahydrofuran was dissoled 1.0 g of methyl N-(4-chlorobenzyloxycarbonyl)tyrosinate. To the solution was slowly added 280 mg of sodium aluminium hydride with stirring and the mixture was stirred for two hours. After addition of 50 ml of 1N hydrochloric acid, the mixture was concentrated in vacuo. The residue was extracted with ethyl acetate and the extract was washed with water, dried and concentrated to dryness. The residue was crystallized from ethyl acetate-petroleum ether to give 610 mg of N-(4-chlorobenzyloxycarbonyl)-tyrosinol: yield 66%.

Provenance & Evidence