反应详情

In 30 ml of tetrahydrofuran was dissoled 1.0 g of methyl N-(4-chlorobenzyloxycarbonyl)tyrosinate. To the solution was slowly added 280 mg of sodium aluminium hydride with stirring and the mixture was stirred for two hours. After addition of 50 ml of 1N hydrochloric acid, the mixture was concentrated in vacuo. The residue was extracted with ethyl acetate and the extract was washed with water, dried and concentrated to dryness. The residue was crystallized from ethyl acetate-petroleum ether to give 610 mg of N-(4-chlorobenzyloxycarbonyl)-tyrosinol: yield 66%.

1. stirringthe mixture was stirred for two hours
2. concentrationthe mixture was concentrated in vacuo
3. extractionThe residue was extracted with ethyl acetate
4. washthe extract was washed with water
5. customdried
6. concentrationconcentrated to dryness
7. customThe residue was crystallized from ethyl acetate-petroleum ether