Potassium Hydroxide → 3-(2',4'-Difluoro-4-biphenylyl)-3-hydroxybutyric acid

HRID 1439031Notes

Reaction equation

HRID 1439031 reaction equation
C([O:3][C:4](=[O:23])[CH2:5][C:6]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[F:22])=[CH:11][CH:10]=1)([OH:8])[CH3:7])C.[OH-].[K+]>C(O)C>[F:22][C:16]1[CH:17]=[C:18]([F:21])[CH:19]=[CH:20][C:15]=1[C:12]1[CH:13]=[CH:14][C:9]([C:6]([OH:8])([CH3:7])[CH2:5][C:4]([OH:23])=[O:3])=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 538342513-(2',4'-Difluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester

Product 1

HCID 213225833-(2',4'-Difluoro-4-biphenylyl)-3-hydroxybutyric acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10 g. of 3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester are dissolved in 50 ml. of ethanol and the solution is heated under reflux with 2 g. of KOH for 3 hours, evaporated and worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid, m.p. 121°-123°.

Workup

  1. temperatureunder reflux with 2 g
  2. customevaporated

Sources & evidence

ORD record
ord-1e0f4250ab89497c96488a23b4cf1cd1
Source dataset
uspto-grants-1977_11
Patent number
US04057647

Reaction notes

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