3-(2',4'-Difluoro-4-biphenylyl)butyric acid ethyl ester → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid

HRID 1439049Notes

Reaction equation

HRID 1439049 reaction equation
C([O:3][C:4](=[O:22])[CH2:5][CH:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[F:21])=[CH:10][CH:9]=1)[CH3:7])C>O>[F:21][C:15]1[CH:16]=[C:17]([F:20])[CH:18]=[CH:19][C:14]=1[C:11]1[CH:12]=[CH:13][C:8]([CH:6]([CH3:7])[CH2:5][C:4]([OH:22])=[O:3])=[CH:9][CH:10]=1

Participants

3

Reactant 1

HCID 543401873-(2',4'-Difluoro-4-biphenylyl)butyric acid ethyl ester

Product 1

HCID 213225403-(2',4'-Difluoro-4-biphenylyl)butyric acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1 g. of 3-(2',4'-difluoro-4-biphenylyl)butyric acid ethyl ester and 100 ml. of water is heated to 180° in an autoclave for 24 hours. It is cooled and worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)butyric acid, m.p. 109°-110°.

Workup

  1. additionA mixture of 1 g
  2. temperatureIt is cooled

Sources & evidence

ORD record
ord-dc11eeb6e41745f5be9fb45598cb2e3c
Source dataset
uspto-grants-1977_11
Patent number
US04057647

Reaction notes

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