Diazomethane → 3-(2',4'-Difluoro-4-biphenylyl)-2-butenoic acid methyl ester

HRID 1439050Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1439050
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15]([CH3:20])=[CH:16][C:17]([OH:19])=[O:18])=[CH:11][CH:10]=1.[N+](=[CH2:23])=[N-]>C1COCC1>[CH3:23][O:18][C:17](=[O:19])[CH:16]=[C:15]([C:12]1[CH:13]=[CH:14][C:9]([C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[F:1])=[CH:10][CH:11]=1)[CH3:20]

Komponenten

4

Edukt 2

HCID 9550DiazomethaneHCID 540100683-(2',4'-Difluoro-4-biphenylyl)-2-butenoic acid

Produkt 1

HCID 536963323-(2',4'-Difluoro-4-biphenylyl)-2-butenoic acid methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

1 g. of 3-(2',4'-difluoro-4-biphenylyl)-2-butenoic acid is dissolved in 10 ml. of THF and an ethereal solution of diazomethane is added dropwise, with stirring, until no further evolution of nitrogen is observed. After 20 minutes, the mixture is evaporated to give 3-(2',4'-difluoro-4-biphenylyl)-2-butenoic acid methyl ester, m.p. 90°-92°.

Aufarbeitung

  1. customthe mixture is evaporated

Quellen und Nachweise

ORD-Eintrag
ord-ccff711a460d4437afca92b2d3a520b9
Quelldatensatz
uspto-grants-1977_11
Patentnummer
US04057647

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