HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazomethane → 3-(2',4'-Difluoro-4-biphenylyl)-2-butenoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | 3-(2',4'-Difluoro-4-biphenylyl)-2-butenoic acid | HCID 54010068 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(2',4'-Difluoro-4-biphenylyl)-2-butenoic acid methyl ester | HCID 53696332 | — |
Reaction Steps
1 g. of 3-(2',4'-difluoro-4-biphenylyl)-2-butenoic acid is dissolved in 10 ml. of THF and an ethereal solution of diazomethane is added dropwise, with stirring, until no further evolution of nitrogen is observed. After 20 minutes, the mixture is evaporated to give 3-(2',4'-difluoro-4-biphenylyl)-2-butenoic acid methyl ester, m.p. 90°-92°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04057647 |
| Source dataset | uspto-grants-1977_11 |
| ORD ID | ord-ccff711a460d4437afca92b2d3a520b9 |
| Source note | uspto-grants-1977_11 |