HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Dioxide → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Dioxide | HCID 280 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | HCID 54297923 | HCID 54297923 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3-(2',4'-Difluoro-4-biphenylyl)butyric acid | HCID 21322540 | — |
Reaction Steps
A solution of crude 1-(2',4'-difluoro-4-biphenylyl)-ethylmalonic acid, obtained by saponifying 2 g. of 1-(2',4'-difluoro-4-biphenylyl)ethylmalonic acid diethyl ester with ethanolic KOH under N2, in 20 ml. of acetic acid and 20 ml. of 15% HCl is heated under reflux under N2 until evolution of CO2 has ceased. After cooling, the customary work up gives 3-(2',4'-difluoro-4-biphenylyl)butyric acid, m.p. 109°-110°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04057647 |
| Source dataset | uspto-grants-1977_11 |
| ORD ID | ord-3ef7bec1da8b427386ca93d98e2347c6 |
| Source note | uspto-grants-1977_11 |