反应详情

A solution of crude 1-(2',4'-difluoro-4-biphenylyl)-ethylmalonic acid, obtained by saponifying 2 g. of 1-(2',4'-difluoro-4-biphenylyl)ethylmalonic acid diethyl ester with ethanolic KOH under N2, in 20 ml. of acetic acid and 20 ml. of 15% HCl is heated under reflux under N2 until evolution of CO2 has ceased. After cooling, the customary work up gives 3-(2',4'-difluoro-4-biphenylyl)butyric acid, m.p. 109°-110°.

1. temperatureAfter cooling