Hydrochloric Acid → HCID 178479163, compound

Participants

Reaction Steps

HCl was hydrolyzed with 6N HCl and produced 5,6-dihydro-5-azacytosine hydrochloride. This has a melting point of 259°-26l°. In order to show the conformity of structure, 5-azacytosine hydrochloride, which is commercially available, was reduced with sodium borohydride to make 5,6- dihydro-5-azacytosine. This compound had a melting point of 189°-190°. HCl acid addition salt was formulated from the free base by treatment with HCl to produce 5,6-dihydro-5-azacytosine hydrochloride with a melting point of 259°-261° which is the same melting point as was obtained from the hydrolysis reaction. There was no depression of the mixed melting point.

Provenance & Evidence