Hydrochloric Acid → HCID 178479163, compound

HRID 1439244Notes

Reaction equation

[ClH:1].[NH:2]1[CH:9]=[N:8][C:6]([NH2:7])=[N:5][C:3]1=[O:4].[BH4-].[Na+].N1CNC(N)=NC1=O.Cl>>[ClH:1].[NH:2]1[CH2:9][NH:8][C:6]([NH2:7])=[N:5][C:3]1=[O:4]

Participants

Reactant 4

HCID 313Hydrochloric Acid2×

HCID 4311764Sodium borohydride

HCID 178479158HCID 178479158, compound

HCID 178509012HCID 178509012, compound

Product 1

HCID 178479163HCID 178479163, compound

Procedure

HCl was hydrolyzed with 6N HCl and produced 5,6-dihydro-5-azacytosine hydrochloride. This has a melting point of 259°-26l°. In order to show the conformity of structure, 5-azacytosine hydrochloride, which is commercially available, was reduced with sodium borohydride to make 5,6- dihydro-5-azacytosine. This compound had a melting point of 189°-190°. HCl acid addition salt was formulated from the free base by treatment with HCl to produce 5,6-dihydro-5-azacytosine hydrochloride with a melting point of 259°-261° which is the same melting point as was obtained from the hydrolysis reaction. There was no depression of the mixed melting point.

Sources & evidence

ORD record: ord-f5043949032c40a1a71bc8b17c5befee
Source dataset: uspto-grants-1977_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04058602

Reaction notes

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