Hydrochloric Acid → HCID 21398897, compound

HRID 1439246Notes

Reaction equation

HRID 1439246 reaction equation
[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]([OH:22])([C:18]([F:21])([F:20])[F:19])[C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=1[C:23]([O:25]CC)=O)=[O:5])[CH3:2].[OH-].[Na+].Cl>>[CH2:1]([N:3]1[C:23](=[O:25])[C:8]2[C:7](=[CH:12][CH:11]=[C:10]([C:13]([OH:22])([C:18]([F:21])([F:19])[F:20])[C:14]([F:17])([F:16])[F:15])[CH:9]=2)[NH:6][C:4]1=[O:5])[CH3:2]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54140730HCID 54140730, compound

Product 1

HCID 21398897HCID 21398897, compoundYield 98.3%

Procedure

Combine 4.02 g (10 mmole) of N-ethyl-N'-[4-(hexafluoro-2-hydroxy-2-propyl)-2-(ethoxycarbonyl)phenyl]urea with 21 ml (20 mmole) 1N NaOH and stir for 1 minute. Acidify the reaction with 1N HCl and extract with 100 ml of Et2O. Dry and concentrate the extract to obtain 3.5 g of white solid. Recrystallize from Et2O-hexane to obtain 2.5 g of white solid 3-ethyl-6-(hexafluoro-2-hydroxy-2-propyl)quinazoline-2,4-dione; m.p. 268°-270° C.

Workup

  1. extractionextract with 100 ml of Et2O
  2. customDry
  3. concentrationconcentrate the
  4. extractionextract

Sources & evidence

ORD record
ord-7ff83aa7d06b4d48aa2f8aba9d976f11
Source dataset
uspto-grants-1977_11
Patent number
US04058612

Reaction notes

Loading…