反应详情

To a suspension of 2-(3-pyridyl)-imidazole (1.5 g., 0.01 moles) in chloroform (150 ml.) is added dropwise with stirring over one hour at reflux N-chlorosuccinimide (2.6 g., 0.02 moles). The reaction mixture is heated three hours at reflux. After cooling, the solvent is removed at 20 mm. and the residue triturated with water while heating on a steam bath. The resulting solid is filtered and after recrystallization from acetonitrile 400 mg. of 2-(3-pyridyl)-4,5-dichloroimidazole is obtained, m.p. 237°-238° C.

1. additionis added dropwise
2. temperatureThe reaction mixture is heated three hours
3. temperatureat reflux
4. temperatureAfter cooling
5. customthe solvent is removed at 20 mm
6. customand the residue triturated with water
7. temperaturewhile heating on a steam bath
8. filtrationThe resulting solid is filtered
9. customafter recrystallization from acetonitrile 400 mg