5,6-Dimethyl-2,3-pyrazinedicarboxylic acid → 5,6-dimethylpyrazine-2-carboxylic Acid
Reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([C:12]([OH:14])=[O:13])[C:5](C(O)=O)=[N:6][C:7]=1[CH3:8]>ClC1C=CC=CC=1Cl>[CH3:8][C:7]1[N:6]=[CH:5][C:4]([C:12]([OH:14])=[O:13])=[N:3][C:2]=1[CH3:1]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 170 °C
Procedure
A suspension of 5,6-dimethylpyrazine-2,3-dicarboxylic acid (110 g.) in 1,2-dichlorobenzene (330 cc.) is heated at a temperature of about 170° C. until the evolution of gas ceases. The reaction mixture is then cooled to a temperature of about 20° C., after which the insoluble product is filtered off and washed with diisopropyl ether (6 × 25 cc.). After drying, 5,6-dimethylpyrazine-2-carboxylic acid (66.4 g.), melting at 187° C., is obtained.
Workup
- temperatureThe reaction mixture is then cooled to a temperature of about 20° C.
- filtrationafter which the insoluble product is filtered off
- washwashed with diisopropyl ether (6 × 25 cc.)
- customAfter drying
Sources & evidence
- ORD record
- ord-9d25ebb630b6419c83daafe9de8eac1f
- Source dataset
- uspto-grants-1977_11
- Patent number
- US04058611
Reaction notes
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