5,6-Dimethyl-2,3-pyrazinedicarboxylic acid → 5,6-dimethylpyrazine-2-carboxylic Acid

Participants

Reaction Conditions

Reaction Steps

A suspension of 5,6-dimethylpyrazine-2,3-dicarboxylic acid (110 g.) in 1,2-dichlorobenzene (330 cc.) is heated at a temperature of about 170° C. until the evolution of gas ceases. The reaction mixture is then cooled to a temperature of about 20° C., after which the insoluble product is filtered off and washed with diisopropyl ether (6 × 25 cc.). After drying, 5,6-dimethylpyrazine-2-carboxylic acid (66.4 g.), melting at 187° C., is obtained.

Provenance & Evidence