3-Methoxythiophene → HCID 14888371, compound

HRID 1439257Notes

Reaction equation

HRID 1439257 reaction equation
[CH3:1][O:2][C:3]1[CH:7]=[CH:6][S:5][CH:4]=1.C([Li])CCC.[S].Cl[CH:15]([OH:17])[CH3:16]>>[CH3:1][O:2][C:3]1[CH:7]=[CH:6][S:5][C:4]=1[CH2:16][CH2:15][OH:17]

Participants

5

Reactant 4

HCID 1402493-MethoxythiopheneHCID 5362487SulfurHCID 126390351-Chloroethan-1-olHCID 178418339Butyllithium

Product 1

HCID 14888371HCID 14888371, compound

Procedure

The compound is produced analogously to Example 1 from 11.4 g. (100 mmol) of 3-methoxythiophene, 45.5 ml. (about 100 mmol) of about 22% butyllithium solution (in hexane), 3.2 g. (100 mmol) of sulfur, and 8.05 g. (100 mmol) of chloroethanol. Bulb tube distillation at 0.04 torr (bath temperature: 118°-129°) yields the alcohol as a slightly yellow oil.

Workup

  1. customThe compound is produced analogously to Example 1 from 11.4 g
  2. distillationBulb tube distillation at 0.04 torr (bath temperature: 118°-129°)

Sources & evidence

ORD record
ord-9fec83b6abb44005a573c29f01d39e1d
Source dataset
uspto-grants-1977_11
Patent number
US04058619

Reaction notes

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