反应详情

温度

150 °C

A mixture of 7.66 g of sodium 4-(n-hexadecylamino)benzoate, 7.55 g of 4-chloro-1-butanol, and 20.0 ml of hexamethylphosphoramide is stirred at 150° C for two hours, allowed to cool, and poured into water. The solid is collected by filtration and then is dissolved in methylene chloride. The solution is washed with water, dried, and evaporated. The residual solid is crystallized from hexane to yield 4-hydroxybutyl 4-(n-hexadecylamino)benzoate as a white solid, mp 61°-63° C.

1. temperatureto cool
2. filtrationThe solid is collected by filtration
3. dissolutionis dissolved in methylene chloride
4. washThe solution is washed with water
5. customdried
6. customevaporated
7. customThe residual solid is crystallized from hexane