3-Chloro-1,2-propanediol → HCID 21326946, compound

HRID 1439299Notes

Reaction equation

HRID 1439299 reaction equation
[CH2:1]([NH:20][C:21]1[CH:29]=[CH:28][C:24]([C:25]([OH:27])=[O:26])=[CH:23][CH:22]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19].[H-].[Na+].Cl[CH2:33][CH:34]([OH:37])[CH2:35][OH:36]>CN(C)P(N(C)C)(N(C)C)=O>[CH2:1]([NH:20][C:21]1[CH:22]=[CH:23][C:24]([C:25]([O:27][CH2:33][CH:34]([OH:37])[CH2:35][OH:36])=[O:26])=[CH:28][CH:29]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]

Participants

5

Reactant 3

HCID 72903-Chloro-1,2-propanediolHCID 24758Sodium hydrideHCID 205563094-(Nonadecylamino)benzoic acid

Product 1

HCID 21326946HCID 21326946, compound

Reagents, catalysts & solvents 1

HCID 12679HexamethylphosphoramideSolvent

Procedure

A solution of 8.05 g. of 4-(n-nonadecylamino)benzoic acid in 25 ml. of hexamethylphosphoramide is treated with sodium hydride and then 1-chloro-2,3-propanediol in the manner described in Example 2 to yield 2,3-dihydroxypropyl 4-(n-nonadecylamino)benzoate as a white solid.

Sources & evidence

ORD record
ord-ba529f5b2cbc497abae9eeaad789552c
Source dataset
uspto-grants-1977_11
Patent number
US04058550

Reaction notes

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