Triethylamine → HCID 131710808, compound

HRID 1439507Notes

Reaction equation

HRID 1439507 reaction equation
S(C1C=CC(C)=CC=1)(O)(=O)=O.C1(C([NH:31][CH:32]2[C:57](=[O:58])[N:34]3[CH:35]([C:40]4[N:41](CC5C=CC(OC)=CC=5)[C:42](=[O:47])[CH2:43][C:44](=[O:46])[N:45]=4)[C:36]([CH3:39])([CH3:38])[S:37][C@H:33]23)(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[OH-].[Na+].[OH-].[K+].C(N(CC)CC)C>O>[NH2:31][CH:32]1[C:57](=[O:58])[N:34]2[CH:35]([C:40]3[NH:41][C:42](=[O:47])[CH2:43][C:44](=[O:46])[N:45]=3)[C:36]([CH3:38])([CH3:39])[S:37][C@H:33]12

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 14797Potassium HydroxideHCID 14798Sodium HydroxideHCID 131710809HCID 131710809, compound

Product 1

HCID 131710808HCID 131710808, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The tosylate salt of Example 8 is converted to the free base form by neutralization with one equivalent of base such as sodium hydroxide, potassium hydroxide or triethylamine in water followed by freeze-drying of the aqueous mixture.

Workup

  1. customby freeze-drying of the aqueous mixture

Sources & evidence

ORD record
ord-bc1a9c519ecd425bbdd4537cae8c29bd
Source dataset
uspto-grants-1977_11
Patent number
US04060524

Reaction notes

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