Hydrochloric Acid → HCID 178486336, compound

HRID 1439513Notes

Reaction equation

HRID 1439513 reaction equation
[C:1]([C:9]1[C:18]([CH2:19][O:20]C(=O)C)=[N+:17]([O-:24])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N+:10]=1[O-:25])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH3:27]O>>[CH3:27][O:8][C:1]1([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:9]2=[N+:10]([O-:25])[C:11]3[C:16]([N+:17]([O-:24])=[C:18]2[CH2:19][O:20]1)=[CH:15][CH:14]=[CH:13][CH:12]=3

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 178475874HCID 178475874, compound

Product 1

HCID 178486336HCID 178486336, compoundYield 61%

Procedure

A stirred suspension of 0.50 g. (1.47 mmol.) of 2-benzoyl-3-acetoxymethylquinoxaline 1,4-dioxide in 10 ml. of methanol was saturated with dry hydrogen chloride. The reaction mixture was stirred at room temperature for three days and then the suspended solid was removed by filtration. The solid was washed with methanol, and dried, to give 0.28 g. (61% yield ) of 1-methoxy-1-phenyl-1,3-dihydrofuro[3,4-b]quinoxaline 4,9-dioxide, m.p. 153°-155° C.

Workup

  1. additionA stirred suspension of 0.50 g
  2. customthe suspended solid was removed by filtration
  3. washThe solid was washed with methanol
  4. customdried
  5. customto give 0.28 g

Sources & evidence

ORD record
ord-5fb40f12da9347ffb6ed6298b560e3a2
Source dataset
uspto-grants-1977_11
Patent number
US04060523

Reaction notes

Loading…