Ethylene Glycol → 1-[p-(2-Thenoyl)phenyl]cyclopropanecarboxylic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of 10 parts of 1-[p-(2-thenoyl)phenyl]cyclopropanecarbonitrile, 3.92 parts of potassium hydroxide, 35 parts of ethylene glycol and 3.5 parts of water is stirred for 48 hours while heating at 140° C. The reaction mixture is poured onto water, stirred with activated charcoal and filtered over hyflo. The filtrate is acidified with hydrochloric acid and the product is extracted with ether. The latter is washed with water, dried, filtered and evaporated. The solid residue is crystallized from acetonitrile, yielding 6.1 parts of 1-[p-(2thenoyl)phenyl]cyclopropanecarboxylic acid; mp. 165.9° C (dec.).

Provenance & Evidence