Hydrogen Bromide → HCID 20338299, compound

HRID 1439603Notes

Reaction equation

HRID 1439603 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16]O)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[BrH:18]>>[BrH:18].[BrH:18].[OH:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][Br:18])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 47425864-(4-Methoxyphenyl)-1-piperazineethanol

Product 1

HCID 20338299HCID 20338299, compound

Procedure

1-(p-Methoxyphenyl)-4-(2-hydroxyethyl)piperazine (10 g) was refluxed 20 hours with 100 ml 48% HBr and concentrated as far as possible on the rotovap. The mixture was filtered and washed with acetone to give a solid which was recrystallized from alcohol to give the product.

Workup

  1. concentrationconcentrated as far as possible on the rotovap
  2. filtrationThe mixture was filtered
  3. washwashed with acetone
  4. customto give a solid which
  5. customwas recrystallized from alcohol
  6. customto give the product

Sources & evidence

ORD record
ord-2fa1ee899ff44c61ba51446d04ed67db
Source dataset
uspto-grants-1977_11
Patent number
US04060526

Reaction notes

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